Antihypertensives Market To 2016

In 2009, the global anti-hypertensive market was estimated to be worth $27.2 billion, representing a Compound Annual Growth Rate (CAGR) of 5.0% between 2002 and 2009. The market is forecast to reach $30 billion by 2016, indicating a CAGR of 1.5% between 2009 and 2016. The primary reason for slight and gradual growth in the market is the patent expiries of major blockbusters, which are expected to decrease the annual cost of therapy after 2007.

For Sample Pages, please click or add the below link to your browser:
http://www.gbiresearch.com/RequestSamplePages.aspx?ID=Antihypertensives-Market-to-2016-Generic-Erosion-Following-Patent-Expiry-of-Major-ARBs-to-Impact-the-Market&Title=Pharmaceuticals_and_Healthcare&ReportType=Industry_Report

The global anti-hypertensive market is expected to witness a series of patent expiries between 2007 and 2015, which includes most of the top selling blockbuster drugs in the anti-hypertensive market. The major drugs that are set to lose patent protection include Novartiss Diovan (2012), Sanofi Aventiss Avapro (2012), Novartiss Exforge (2012), Takeda/AstraZenecas Blopress/Atacand (2012), Pfizers Revatio (2012), Actelions Tracleer (2015), and United Therapeutics Remodulin (2014). All these drugs together accounted for more than $19.4 billion in revenues in 2009. Mercks Cozaar patent expired in April 2010. The sales of Cozaar for the year 2009 were $3.6 billion. Pfizers Norvasc, which was once the worlds most prescribed drug for hypertension and angina, saw a sales decline of 12% in 2009 due to genericization in 2007. Thus, the series of upcoming patent expiries in the hypertension as well as PAH markets are set to lead to a decline in the market in the near future. However, due to increased usage of fixed dose-combinations and the entry of generics, the market is expected to rise slightly after 2015.

The current anti-hypertensive pipeline does offer some promising novel products, such as SPP635, Actos, LCZ696, QT1571, ACT-293987, PS-433540, Macitentan and Riociguat, indicated for the treatment of hypertension and PAH. However, the revenues generated from these products are not expected to completely make up for the revenue losses due to patent expiries. Thus, the overall global anti-hypertensive market is expected to show flat growth during the forecast period.

GBI Research, a leading business intelligence provider, has released its latest research Antihypertensives Market to 2016 – Generic Erosion Following Patent Expiry of Major ARBs to Impact the Market. The report provides in-depth analysis of the unmet needs, drivers and barriers that affect the global antihypertensive market. The report analyzes the markets for antihypertensive disorders in the US, the top five markets in Europe (the UK, Germany, France, Italy and Spain), and Japan. Treatment usage patterns, sales, prices and volumes are forecast until 2016 for the key geographies as well as the leading therapeutic segments. Furthermore, the report provides competitive benchmarking for the leading companies and analyzes the mergers, acquisitions and licensing agreements that shape the global markets.

For further details, please click or add the below link to your browser:
http://www.gbiresearch.com/Report.aspx?ID=Antihypertensives-Market-to-2016-Generic-Erosion-Following-Patent-Expiry-of-Major-ARBs-to-Impact-the-Market&ReportType=Industry_Report&Title=Pharmaceuticals_and_Healthcare

Visit our report store: http://www.gbiresearch.com

For more details contact:
[emailprotected]
North America: +1 646 395 5477
Europe: +44 207 753 4299
+44 1204 543 533
Asia Pacific: +91 40 6616 6782

Cross Country Running Shoes

One of the greatest sports I can think of is cross country running. A popular sport in high school and college athletics, and also a popular activity among outdoor enthusiast and runners in general, cross country running offers the opportunity to get out into nature and experience it in a very personal and intense way. If you enjoy running, either for the health benefits or the runners high, you should try getting out to one of your favorite spots in nature, find a good trail, lace up a decent pair of trail running shoes and go running through the forest.

I remember when I first went to purchase a pair of cross country running sneakers as a high school freshman. The sales person told me about durability and ruggedness and other things he had no knowledge about and sold me a pair of low quality tennis shoes. Well, needless to say I paid for that mistake with injuries and terrible times, but I learned a valuable lesson. It is important to be informed before going to shop for an important item like a trail running shoe. Your health and well being may depend on it, and you cant always rely on the sales clerk to know what he is talking about.

If you are going to be running cross country, you will inevitably find yourself running on every kind of terrain imaginable, from pavement to track to grass to trails through the woods. You will often find yourself jumping over roots and rocks, making sudden inclines or declines and crossing drastically from one type of surface to the next. However, ultimately you are still running, and a running shoe is what you are looking for.

trail running footwear is a running shoe that is generally a little sturdier and focuses on delivering a lot of cushioning and lateral support. The often treacherous and unpredictable paths a cross country runner takes requires a shoe that can withstand a lot of abuse. Trail running shoes are often made to be a little more weather and element resistant, as you will often find yourself trekking through mud, wet grass and perhaps even snow.

One sacrifice trail runners will sometimes make is in weight, as the added protection and durability come at the cost of more material and therefore more overall weight in the mens or womens running shoe. However, as you go up in quality, the trail running footwear will get lighter and lighter, until you find a range of durable, supportive, quality running shoes with the appropriate tread on the bottom and support to survive the rugged sport of cross country running.

Fitting a trail running shoe is exactly like fitting any other athletic footwear. Trail running shoes come in all the varieties that other running shoes do, so choose an appropriate style of shoe for your particular needs. When you try the running shoes on, put on both pair and walk around the store a little bit. Crouch down and bend the toe to see how flexible and comfortable they are, and whether or not they rub around your ankles. Try them on with a pair of socks that are like to the ones you run in, as many cross country runners will have special socks that they wear. Move side to side, jump a little bit and run a short distance.

The shoe should fit snug but not pinch your foot. This is especially important in trail running shoes, because the terrain you will be moving across is so varied and uneven. If a shoe pinches your toes, the result can be anything from twisted ankles to bunions to stress fractures. The runners stride depends on a certain range of motion to operate properly during a step, and the trail running shoes you choose should enhance and support that range of motion, not inhibit it.

Direct Sales Is One Of The Best Ways To Make Big Money

There are many ways to make big money on the Internet. I personally have found direct sales to be one of the best ways to make money online and make alot of it. Why do I say that?

1. Higher commissions. Companies are willing to compensate you for your efforts at a higher commission rate than you can make in other ways.

For example, Primo Vacations is a big ticket direct sale opportunity. You earn $500 on every $697 sale you make. This works out to over a %70 commission rate.

Some companies will cut checks directly to you. In the Primo Vacations example you are your own business owner and the money is paid directly to you on a completed sale.

There are examples of high commission rates in other business models such as affiliate marketing. In many ways selling other people’s products as an affiliate marketer is a direct sales approach.

ClickBank is an example of an affiliate program where you can earn up to 75% commissions selling ebooks. The downside to this is these are not really big ticket items, so you have to make more sales to really make big money.

2. You are in control. People who want to have control over their income love direct sales opportunities.

When you go to work your boss tells you how much are going to make. Generally every Friday you get a paycheck and you know exactly what it is going to be.

In direct sales the more you sell the more you are going to earn. For people who are self-motivated this is an excellent way to make a lot of money.

Unlike other business models such as network marketing, you are not relying on a downline to earn you money. This is why so many people fail in network marketing.

Unless you are in an MLM program that offers products that pay a high commission, many times people never make enough money to justify staying in business. Therefore they quit.

3. Easy to focus. This is one of my favorite things about direct sales.

Your focus is strictly on selling your product. You may need to do marketing on the Internet to drive traffic to your website.

You might need to follow up with people via phone or email to answer questions. However, your focus is on generating leads and selling your product.

You are not worried about blogging every day. You are not worried about adding new web pages. If you can get focused on selling direct sales is the way to go.

There is no doubt the direct sales is one of the best ways to make big money if you promote the right product. Look for big ticket items that will pay you commissions of $500 or more and you can make a lot of money.

An Alternative To Venture Capital In The Food And Beverage Industry

If you are an entrepreneur with a small food or beverage company looking to take it to the next level, this article should be of particular interest to you. Your natural inclination may be to seek venture capital or private equity to fund your growth, but that might not be the best path for you to take. We have created a hybrid M&A model designed to bring the appropriate capital resources to you entrepreneurs. It allows the entrepreneur to bring in smart money and to maintain control.

We have taken the experiences of a beverage industry veteran, a food industry veteran and an investment banker and crafted a model that both large industry players and the small business owners are embracing.

I recently connected with two old college mates from the Wharton Business School. We are in what we like to call, the early autumn of our careers after pursuing quite different paths initially. John Blackington is a partner in Growth Partners, a consulting firm that advises food and beverage companies in all aspects of product introduction and market growth. You might say that it has been his life’s work with his initial introduction to the industry as a Coke Route driver during his college summer breaks.

After graduation, Coke hired John as a management trainee in the sales and marketing discipline. John grew his career at Coke and over the next 25 years held various positions in sales, marketing, and business development. John’s entrepreneurial spirit prevailed and he left Coke to consult with early stage food and beverage companies on new product introductions and strategic partnerships.

Steve Hasselbeck is now a food industry consultant after spending 27 years with the various companies that were rolled up into ConAgra. His experience was in managing products and channels. Steve is familiar with almost every functional area within a large food company. He has seen the introduction and the failed introduction of many food industry products.

John’s experience at Coke and Steve’s experience at ConAgra led them to the conclusion that new product introductions were most efficiently and cost effectively the purview of the smaller, nimble, low overhead company and not the food and beverage giants.

Dave Kauppi is now the president of MidMarket Capital, a M&A firm specializing in smaller technology based companies. Dave got the high tech bug early in his business life and pursued a career in high tech sales and marketing. Dave sold or managed in computer services, hardware, software, datacom, computer leasing and of course, a Dot Com. After several experiences of rapid accent followed by an even more rapid decent as technologies and markets changed, Dave decided to pursue an investment banking practice to help technology companies.

Dave, John, and Steve stayed in touch over the years and would share business ideas. In a recent discussion, John was describing the dynamics he saw with new product introductions in the food and beverage industry. He observed that most of the blockbuster products were the result of an entrepreneurial effort from an early stage company bootstrapping its growth in a very cost conscious lean environment.

The big companies, with all their seeming advantages experienced a high failure rate in new product introductions and the losses resulting from this art of capturing the fickle consumer were substantial. When we contacted Steve, he confirmed that this was also his experience. Don’t get us wrong. There were hundreds of failures from the start-ups as well. However, the failure for the edgy little start-up resulted in losses in the $1 – $5 million range. The same result from an industry giant was often in the $100 million to $250 million range.

For every Hansen Natural or Red Bull, there are literally hundreds of companies that either flame out or never reach a critical mass beyond a loyal local market. It seems like the mentality of these smaller business owners is, using the example of the popular TV show, Deal or No Deal, to hold out for the $1 million briefcase. What about that logical contestant that objectively weighs the facts and the odds and cashes out for $280,000?

As we discussed the dynamics of this market, we were drawn to a merger and acquisition model commonly used in the technology industry that we felt could also be applied to the food and beverage industry. Cisco Systems, the giant networking company, is a serial acquirer of companies. They do a tremendous amount of R&D and organic product development. They recognize, however, that they cannot possibly capture all the new developments in this rapidly changing field through internal development alone.

Cisco seeks out investments in promising, small, technology companies and this approach has been a key element in their market dominance. They bring what we refer to as smart money to the high tech entrepreneur. They purchase a minority stake in the early stage company with a call option on acquiring the remainder at a later date with an agreed-upon valuation multiple. This structure is a brilliantly elegant method to dramatically enhance the risk reward profile of new product introduction. Here is why:

For the Entrepreneur: (Just substitute in your food or beverage industry giant’s name that is in your category for Cisco below)

1.The involvement of Cisco – resources, market presence, brand, distribution capability is a self fulfilling prophecy to your product’s success.

2.For the same level of dilution that an entrepreneur would get from a VC, angel investor or private equity group, the entrepreneur gets the performance leverage of smart money. See #1.

3.The entrepreneur gets to grow his business with Cisco’s support at a far more rapid pace than he could alone. He is more likely to establish the critical mass needed for market leadership within his industry’s brief window of opportunity.

4.He gets an exit strategy with an established valuation metric while the buyer helps him make his exit much more lucrative.

5.As an old Wharton professor used to ask, What would you rather have, all of a grape or part of a watermelon? That sums it up pretty well. The involvement of Cisco gives the product a much better probability of growing significantly. The entrepreneur will own a meaningful portion of a far bigger asset.

For the Large Company Investor:

1.Create access to a large funnel of developing technology and products.

2.Creates a very nimble, market sensitive, product development or R&D arm.

3.Minor resource allocation to the autonomous operator during his skunk works market proving development stage.

4.Diversify their product development portfolio – because this approach provides for a relatively small investment in a greater number of opportunities fueled by the entrepreneurial spirit, they greatly improve the probability of creating a winner.

5.By investing early and getting an equity position in a small company and favorable valuation metrics on the call option, they pay a fraction of the market price to what they would have to pay if they acquired the company once the product had proven successful.

Dean Foods utilized this model successfully with their investment in White Wave, the producer of the market leading Silk Brand of organic Soy milk products. Dean Foods acquired a 25% equity stake in White Wave in 1999 for $4 million. While allowing this entrepreneurial firm to operate autonomously, they backed them with leverage and a modest level of capital resources. Sales exploded and Dean exercised their call option on the remaining 75% equity in White Way in 2004 for $224 million. Sales for White Way were projected to hit $420 million in 2005.

Given today’s valuation metrics for a company with White Way’s growth rate and profitability, their market cap is about $1.26 Billion, or 3 times trailing 12 months revenue. Dean invested $5million initially, gave them access to their leverage, and exercised their call option for $224 million. Their effective acquisition price totaling $229 million represents an 82% discount to White Wave’s 2005 market cap.

Dean Foods is reaping additional benefits. This acquisition was the catalyst for several additional investments in the specialty/gourmet end of the milk industry. These acquisitions have transformed Dean Foods from a low margin milk producer into a Wall Street standout with a growing stable of high margin, high growth brands.

Dean’s profits have tripled in four years and the stock price has doubled since 2000, far outpacing the food industry average. This success has triggered the aggressive introduction of new products and new channels of distribution. Not bad for a $5 million bet on a new product in 1999. Wait, let’s not forget about our entrepreneur. His total proceeds of $229 million are a fantastic 5- year result for a little company with 1999 sales of under $20 million.

MidMarket Capital has created this model combining the food and beverage industry experience with the investment banking experience to structure these successful transactions. MMC can either represent the small entrepreneurial firm looking for the smart money investment with the appropriate growth partner or the large industry player looking to enhance their new product strategy with this creative approach.

This model has successfully served the technology industry through periods of outstanding growth and market value creation. Many of the same dynamics are present in the food and beverage industry and these same transaction stru7ctures can be similarly employed to create value.